Appearance A yellow crystalline powder
Identification 1. Melting point 89℃ to 91℃
2.Chemical Reaction The maximum absorbance is 250 to 270.
3. IR Complies with the CRS
4. Complies with the CRS
5. Gives reaction of chlorides
Tests Related substances
(Examine by HPLC) Total impurities not more than 1%
Other individual impurity not more than 0. 5%
Chlorides The solution complies with the limit test for chlorides.
Loss on drying Not more than 1.0 per cent
Assay Lomustine contains not less than 98.5 per cent and not more than the equivalent of 100.5 per cent of 1-(2-chloroethyl)-3-cyclohexyl-1- nitrosourea, calculated with reference to the dried substance.